New study exposes how obesity hormone leptin can “feed” breast cancer cells

(NaturalHealth365)  It’s no secret that obesity increases the risk of cancer, but scientists are now uncovering why.  A study published in The American Journal of Pathology has revealed a hidden mechanism linking body fat to breast cancer progression.  Researchers found that leptin, a hormone produced by fat cells, may do more than regulate appetite.  It can actually fuel the growth of certain breast cancer cells by altering how they process fat.

This discovery shines a light on a biological “bridge” between obesity and cancer, and it may help explain why overweight women – especially after menopause – face higher risks of developing estrogen receptor (ER)-positive breast cancers.

The fat–hormone connection: How leptin feeds tumor growth

Under healthy conditions, leptin helps the brain regulate hunger and energy balance.  But when fat stores expand, leptin levels skyrocket, and that’s when things can go wrong.

The study found that high leptin levels activate an enzyme called stearoyl-CoA desaturase 1 (SCD1) inside breast cancer cells.  This enzyme converts saturated fats into monounsaturated fats, which cancer cells use to build new membranes and fuel rapid growth.

In lab experiments, when researchers blocked SCD1, the cancer cells lost their ability to grow and move aggressively, even when exposed to high leptin levels.  In short, leptin tells the cancer cells to “go,” and SCD1 makes it possible.

These findings go beyond the usual “lose weight” message.  They show that obesity alters the very metabolic environment of the body, creating conditions that support tumor survival and spread.  For women, especially those post-menopause, chronically elevated leptin and disordered fat metabolism may be an invisible driver behind breast cancer recurrence and progression.

Natural ways to protect your body from the inside out

The good news: your daily choices can make a measurable difference.  You can lower leptin resistance, calm inflammation, and support healthier metabolic balance, all of which may help reduce cancer risk.

Here are a few science-backed ways to support healthy fat metabolism and hormone balance naturally:

• Stabilize blood sugar: Reduce refined carbs and processed snacks that drive leptin resistance and chronic inflammation.

• Prioritize fiber and antioxidants: Load your plate with organic leafy greens, berries, cruciferous vegetables, and omega-3-rich foods like flax and wild salmon.

• Move daily: Regular activity, even brisk walking, improves insulin sensitivity and helps normalize leptin signaling.

• Get quality sleep: Leptin and ghrelin (your hunger hormones) are tightly linked to your sleep cycle.  Poor sleep can disrupt both.

• Support liver detoxification: Your liver is your body’s primary filter for hormone and fat metabolism.  Castor oil packs, cruciferous vegetables, and hydration all help keep it functioning optimally.

While there’s no single food or supplement that can “cure” cancer, these lifestyle strategies help restore the metabolic balance your body depends on for long-term defense and repair.

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Sources for this article include:

Sciencedirect.com
News-medical.net

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