Alzheimer’s Disease in Women: How Hormonal Transitions Impact the Brain, New Therapies & More (Video)
In this 25 January 2026 published video, host Peter Attia MD talks with Lisa Mosconi, a world-renowned neuroscientist & the director of the Women’s Brain Initiative at Weill Cornell Medicine, where she studies how sex differences & hormonal transitions influence brain aging & Alzheimer’s disease risk.
In this episode, Lisa explores why Alzheimer’s disease disproportionately affects women & why longer lifespan alone does not explain their nearly twofold risk compared to men. She explains why Alzheimer’s disease may be best understood as a midlife disease for women, beginning decades before symptoms appear, & how menopause represents a fundamental brain event that reshapes brain energy use, structure, & immune signaling. The conversation also examines what advanced brain imaging reveals about preclinical Alzheimer’s disease, estrogen receptors in the brain, & why genetic risks such as APOE4 appear to affect women differently from men.
Finally, Lisa discusses the nuanced evidence around menopause hormone therapy, the legacy of the WHI, her new CARE Initiative to cut women’s Alzheimer’s risk in half by 2050, & practical, evidence-based strategies to support brain health through midlife—including lifestyle, sleep, metabolism, mood, & emerging therapies such as GLP-1 agonists & SERMs (selective estrogen receptor modulators).
https://youtu.be/DfAnIBGwcUk
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