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Top Gut Health Expert: The 4 Nutrients That Get Results Overnight (Video)

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In this 12 January 2026 published video, host Rich Roll talks with Dr. Will Bulsiewicz, a gastroenterologist, New York Times bestselling author, and one of the world’s preeminent authorities on gut health. We discuss the gut-immune connection, the four nutritional workhorses, circadian eating, and why healing sometimes has nothing to do with diet.

https://youtu.be/ilrstCbOBog


  • 00:00:00 Introduction
  • 00:01:27 The Gut-Immune Connection & Chronic Disease
  • 00:05:28 Summary of the Gut-Inflammation Link
  • 00:06:06 Nuance: Genetics and Disease
  • 00:06:56 Innate vs. Adaptive Immunity
  • 00:10:47 The Gut Barrier and Immune Protection
  • 00:12:47 Chronic Low-Grade Inflammation Symptoms
  • 00:14:52 Medical System’s Approach & Testing Limitations
  • 00:16:53 Microbiome Geography & Testing Challenges
  • 00:18:02 Role of the Mucosal Layer
  • 00:18:47 Short Chain Fatty Acids & Gut Health
  • 00:19:40 Self-Diagnosis & Prevalence of Inflammation
  • 00:22:37 The Microbiome as a Life Story
  • 00:23:24 Drivers of Poor Gut Health: Food & Environment
  • 00:24:04 Ultra-Processed Foods & Health Risks
  • 00:26:48 Modern Lifestyle & Loneliness
  • 00:28:31 Sponsor Break
  • 00:31:07 Ultra-Processed Foods: Mechanisms of Harm
  • 00:33:01 Sugar, Salt, and Fat: Microbiome Impact
  • 00:37:59 Hyperpalatability & Overeating
  • 00:40:36 Food Additives & Regulatory Gaps
  • 00:45:42 Personal Agency vs. Systemic Change
  • 00:48:04 Dietary Interventions: Where to Start?
  • 00:52:21 The Four Nutrients: 1. Fiber
  • 00:55:12 Prebiotic Fiber & Resistant Starch
  • 00:57:53 Diversity of Plant Foods
  • 00:59:21 Carnivore Diet & Fiber Debate
  • 01:02:54 Sponsor Break
  • 01:05:59 Short Chain Fatty Acids: Anti-Inflammatory Power
  • 01:09:57 The Four Nutrients: 2. Polyphenols
  • 01:15:35 The Four Nutrients: 3. Omega-3 fats
  • 01:24:52 Seed Oils & Inflammation Debate
  • 01:27:49 The Four Nutrients: 4. Fermented Foods
  • 01:31:06 Recap: The Four Workhorses
  • 01:32:08 Environment, Circadian Rhythm, and Gut Health
  • 01:34:22 Circadian Rhythm & Morning Sunlight
  • 01:42:22 Time-Restricted Eating & Meal Timing
  • 01:47:45 Alcohol & Gut Barrier Disruption
  • 01:52:19 Emotional & Spiritual Health
  • 01:58:41 Sympathetic vs. Parasympathetic Balance
  • 02:03:21 Trauma, Healing, and the Gut
  • 02:09:36 Personal Story: Family, Forgiveness, and Faith
  • 02:24:23 Conclusion: Holistic Health & Final Thoughts



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