Selenium deficiency tied to deadly viruses, neurodegenerative diseases

(NaturalHealth365)  Selenium, an essential trace mineral, is now considered indispensable for maintaining optimum health.  Perhaps less well-known are the frightening implications of a selenium deficiency.  New research suggests that shortages of this mineral may play a role not only in the development of neurodegenerative diseases but also in the emergence of new and dangerous viral strains that could even trigger epidemics.

With well over 100,000 people hospitalized yearly in the United States for influenza viruses – and 20,000 plus losing their lives due to its complications – it has never been more important to understand and address the threat presented by poor selenium status.

Selenium protects against oxidative damage

Selenium exists naturally in soil – and is also found in the bodies of animals and humans, where it performs many important biochemical functions.  These include helping to regulate metabolism, managing normal growth, orchestrating reproduction, neutralizing free radicals, and defending against infections.

Selenium is a component of glutathione peroxidase, the body’s ‘master’ antioxidant, and is incorporated into at least 25 different proteins.  It neutralizes free radicals by rendering them harmless within our bodily fluids.

As a constituent of glutathione, selenium helps protect cardiovascular health by combating the oxidation of fats and reducing the “stickiness” of blood platelets.  It also helps to neutralize toxins.

Selenium deficiencies are more likely to occur in parts of the world where the soil is naturally low in this mineral.  However, recent research suggests that the consequences of poor selenium status may also impact other populations.

Alarming study shows link between selenium and increased virulence of pathogens

In a study conducted at the University of North Carolina at Chapel Hill and published in FASEB – the Federation of American Societies for Experimental Biology journal – researchers found that inadequate selenium intake increased damage caused by the influenza virus.

Even more disturbing, they discovered that the influenza virus mutated when it passed through selenium-deficient mice.  Not only did it emerge more virulent than before, but it could then infect mice with optimal selenium status.

The team also found that the viruses from the selenium-deficient mice had mutations in the gene for the M1 matrix protein, which is associated with viral replication.  Once the virus had mutated, even well-nourished mice were susceptible to the new, more virulent strain.

The findings, which suggested that nutritional deficiencies can promote epidemics by contributing to the emergence of new viral strains, were deemed “disturbing” by the team.

Some researchers believe that the emergence of the Ebola virus – as well as new strains of influenza and the common cold – could stem from viral changes brought about by interactions with selenium-deficient hosts from areas of low soil selenium.  In other words, people from low-selenium areas could act as unwitting “incubators” for more virulent pathogens.

Selenium deficiency allows a benign virus to mutate and damage the heart

A related study found that selenium deficiency can cause coxsackievirus B3 – a normally mild virus – to mutate into a microbe capable of attacking heart muscle.  The resultant heart inflammation is known as Keshan disease – a condition that affects the population in parts of rural China where the soil is deficient in selenium.

In a study published in The Journal of Nutrition, researchers fed mice a selenium-deficient diet for four weeks, then inoculated them with a strain of coxsackievirus B3 that would not normally cause cardiac inflammation.

The deficient mice not only had five times less beneficial glutathione activity than those with adequate selenium but also developed heart damage.  The virus was then inoculated back into the well-nourished mice with adequate selenium.  And the results were troubling – those mice, as well, developed heart damage and myocarditis.

Selenium supplementation can help arrest the progression of serious health problems

While selenium deficiencies can make viruses more dangerous, research demonstrates that supplementary selenium can have beneficial effects.

For example, supplementation with selenium drastically reduces the incidence of hepatitis B in both animals and humans.  In those already infected with hepatitis B, selenium supplementation can prevent the progression of the disease to liver cancer.

Selenium can also help prevent the progression of HIV infection to full-blown AIDS.  A placebo-controlled double-blind study showed that HIV-positive men and women receiving selenium supplementation were admitted to the hospital less often than those who received a placebo.

Selenium supplementation may even benefit those who aren’t deficient

Research shows that supplementation enhances the immune response – even in those with optimal levels.  In a study published in Biological Trace Element Research, researchers found that 200 mcg a day of selenium increased the activity of natural killer cells by 82 percent.

Natural health experts say that 55 micrograms of this mineral a day – the amount recommended by the Institutes of Medicine – may be insufficient to enhance the immune system and prevent cancer.

If you think selenium supplementation is right for you, discuss it first with a trusted holistic healthcare provider.  Good dietary sources of selenium include Brazil nuts, pasture raised (organic) eggs, liver, and sunflower seeds.

Sources for this article include:

NIH.gov
Lifeextension.com
Sciencedaily.com
Jn.nutrition.org

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