Detoxification: How to Detox and Nourish Your Liver for Optimal Health Naturally

Western diet contains high saturated fat, trans fat, and other harmful substances such as sugar, caffeine, pesticides, additive substances, and less in fruits and vegetables.

These types of harmful substances are toxic and induce a shift in microbiota composition in enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation(10).

Some researchers suggested that escalating consumption of fat and sugar in Western countries are associated parallelly in increased incidence of cardiovascular disease during the latter 20th century(10).
Also, according to the report in The American Journal of Pathology and studied mice module, Western diet altered the bile acid profile and elevated liver inflammation(12) as well as promoted other Western-pattern diet-related diseases, including non alcohol fatty liver disease, metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis(11).

Our body’s detoxified functions try to get rid of them everyday. When they fail, the toxins can cause a disruption of hormone production, damage of our body’s detoxification organs and  immune system, leading to hormone imbalance and development of chronic ailments.

Natural Remedies Detox And Nourish Your Liver, include
1. Milk thistle
Milk thistle, a flower plant of the daisy family has been traditionally claimed in treatment of chronic liver disease. 

The herbal medicine contains silymarin with impressive functions in protected liver and  expelled liver toxins.

In a study to compared Cirsium japonicum DC’s flavonoids, liver protection against liver toxicity using carbon tetrachloride (CCl4) with silymarin as a positive control, researchers after taking into account of other co and founders found that silymarin exerts a clear hepatoprotective effects similar to those of Cirsium japonicum DC’s flavonoids aginst toxins caused by injection of carbon tetrachloride (CCl4)(1)

Dr. Ma Q, the lead scientist said, “The results indicated that the pretreatment with C. japonicum flavonoids could significantly reverse CCl4-induced L02 cell viability decrease similarly to silymarin”.

Silymarin is a mixture of flavonoids from Silybum marianum(milk thistle), a traditional European food plant with clear hepatoprotective effects.

2. Licorice
Licorice is a legume plant, native southern Europe and parts of Asia.

The herbal medicine contains a bioactive compound glycyrrhizin, which demonstrated a significantly liver protective effect against liver toxins through suppression of hepatic stellate cell in activation of  liver fibrosis in some studies(3).

According to the even-day intraperitoneal administration of glycyrrhizin (400 mg/kg/day) to 2- to 3-month-old male C57BL/6N mice (mean weight 27 g) against acetaminophen-induced liver damage observed by activity of alanine transaminase and aspartate aminotransferase, application of glycyrrhizin significantly reversed the increased levels of long-chain acylcarnitines in induction of liver damage and toxicity(2).

Further differentiation of the metabolomic assay, suggested that glycyrrhizin exerts a significant protection effect against acetaminophen-induced liver damage by toxic acetaminophen through reversing fatty acid metabolism(2).

3. Tabebuia heptaphylla

Tabebuia heptaphylla is the botanical name:of Pau d’Arco

The herbal plant contains alkaloids, flavonoids, sulfur and essential oils which have a strong effect in enhanced and support the immune activity(4).

The herb displayed a strong hepaprotective effect against liver damage and toxicity, probably due to a major bioactive compound  flavonoids(4).

4. Stilingia root
Stilinga root not only strengthens the immune cells but also prevents and treats food allergies and eczema by stimulating the removal of toxins accumulation in the liver caused by long term eating of preservatives, canned foods, fast foods and excessive alcohol drinking. 

According to the Scovill’s compound syrup of sarsaparilla and stillingia, or, Blood and liver syrup : for the cure of scrofula and all diseases of the blood and liver by A.L. Scovill & Co, stillingia root processes a strong hepaprotective effect against liver disease and liver toxins.

5. Prickly ash
Prickly ash is also known as toothache tree. It has been used traditionally as a digestive aid and to strengthen the nervous system. Prickly ash is considered as a tonic and stimulant herb for the liver and gallbladder.

As a holistic cleanser, Prickly ash eliminates toxins, including liver toxicity(5).

6. St. John wort
St. John wort is also known as tipton weed or klamath weed. 

The herb has been used popularly for ameliorated depression.

Major bioactive flavonoids and 3-O-coumaroylquinic acid process anti-inflammation and antioxidant effects in stimulated the immune system  fighting allergies and in protected liver against  toxins(6).
.
Dr. Aydin A and colleagues, in the study of the effects of St. John wort on hepatic ischemia suggested that application of H. perforatum on rat model exerts a strong liver protection against hepatic ischemia locally and systemically(6),

Its chromone glycosides also showed moderate hepatoprotective activity with EC(50) values of 160.2 microM and 217.7 microM, respectively, against tacrine-induced cytotoxicity in HepG2 cells(7).

7. Fennel 

Fennel contains anethole, polymers and essential oil with function in improved liver and pancreas in the metabolism of fats and sugars.

The herbal  medicine also has a strong effect in dissolved fat deposits of the body and restored damaged liver cells that cause jaundice, hepatitis and other liver disorders(8)(9).

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Sources

(1) Hepatoprotective effect of flavonoids from Cirsium japonicum DC on hepatotoxicity in comparison with silymarin by Ma Q1, Wang LH, Jiang JG(PubMed)

(2) Targeted metabolomic study indicating glycyrrhizin’s protection against acetaminophen-induced liver damage through reversing fatty acid metabolism by Yu J, Jiang YS, Jiang Y, Peng YF, Sun Z, Dai XN, Cao QT, Sun YM, Han JC, Gao YJ(PubMed)

(3) Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis by Florent Duval, Jorge E Moreno-Cuevas, María Teresa González-Garza,Carlos Rodríguez-Montalvo, and Delia Elva Cruz-Vega(PMC)

(4) Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids by Chin-Lin Hsu*†, Gow-Chin Yen‡§1, in The Enzymes, 2014(Science Direct)

(5) Facts and benefits of Prickly Ash(Health Benefits Times)
(6) The effects of Hypericum perforatum on hepatic ischemia- -reperfusion injury in rats by Aydin A, Sakrak O, Yilmaz TU, Kerem M(PubMed)
(7) Chromone glycosides and hepatoprotective constituents of Hypericum erectum by An RB1, Jeong GS, Beom JS, Sohn DH, Kim YC(PubMed)
(8) Protective effect of anethol dithiolthione against acetaminophen hepatotoxicity in mice by Warnet JM1, Christen MO, Thevenin M, Biard D, Jacqueson A, Claude JR(PubMed)
(9) Protective mechanism of anethole on hepatic ischemia/reperfusion injury in mice by Cho HI1, Kim KM, Kwak JH, Lee SK, Lee SM(PubMed)
(10)Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation by Agus A1, Denizot J1, Thévenot J1,2, Martinez-Medina M1, Massier S1, Sauvanet P1,3, Bernalier-Donadille A4, Denis S2, Hofman P5, Bonnet R1,6, Billard E1,7, Barnich N(PubMed)
(11) Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis by Schierwagen R1, Maybüchen L1, Zimmer S2, Hittatiya K3, Bäck C4, Klein S1, Uschner FE1, Reul W1, Boor P5, Nickenig G2, Strassburg CP1, Trautwein C4, Plat J6, Lütjohann D7, Sauerbruch T1, Tacke F4, Trebicka J(PubMed)
(12) Western Diet Consumption May Increase Risk of Chronic Liver Inflammation in Men by All India | NDTV Food Desk | Updated: July 12, 2017 16:05 IST(NDTV)